Evidence map›Paper›PMID 41450480›Full record

ArticleIDCases2025

Syphilitic osteitis of the skull presenting as a complication of secondary syphilis.

Kristoffer E Leon, Daniel J Minter, Bryn A Boslett

Abstract readCase Reports
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristoffer E LeonDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Daniel J MinterDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.
Bryn A BoslettDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syphilis still remains a common infection in the United States with increasing prevalence in the last two decades. With HIV co-infection (even if well-controlled), syphilis as well as other infections can have unusual presentations. In this case report, we present a case of secondary syphilis complicated by neurosyphilis and osteitis of the skull treated with a prolonged course of intravenous penicillin. We review the published literature regarding syphilitic calvarial osteitis, a rare manifestation of this protean infection, to discuss areas of uncertainty regarding diagnostic and treatment decisions.

Indexed as

HIVOsteitisSexually transmitted infectionsSyphilis

Identifiers

PMID41450480
PMCPMC12731268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.