ArticleCureus2025
The Impact of Maternal COVID-19 Severity on Obstetrical and Neonatal Outcomes: A Retrospective Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- COVID-19 and Global Perinatal Health: Lessons Learned on Maternal-Neonatal Outcomes, Infant Feeding Practices, and Health Care Economics across Income Settings.American journal of perinatology · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPregnancy induces physiological and immunological changes that increase susceptibility to severe outcomes from viral respiratory infections. Global meta-analyses have established that coronavirus disease 2019 (COVID-19) in pregnancy is associated with significantly elevated risks of adverse outcomes, including maternal ICU admission and preterm birth. However, region-specific data from Lebanon and the Middle East are scarce. This study aimed to evaluate the association between COVID-19 severity and obstetrical/neonatal outcomes in a Lebanese cohort. MATERIALS AND
methodsA retrospective, observational, monocentric study was conducted at Sheikh Ragheb Harb University Hospital. We included 110 hospitalized pregnant women with PCR-confirmed COVID-19 and their neonates admitted during 2021. The primary outcome was a composite of adverse neonatal outcomes (neonatal COVID-19 positivity or NICU admission). Secondary outcomes included individual neonatal components (birth weight, APGAR scores) and maternal outcomes (mode of delivery, preterm birth): statistical analyses employed chi-square tests, t-tests, and univariate logistic regression.
resultsMost patients (86.4%, n=95) had asymptomatic/mild COVID-19, while 13.6% (n=15) had moderate/severe disease. Moderate/severe maternal COVID-19 was significantly associated with an increased likelihood of cesarean delivery (odds ratio (OR)=4.70, 95% confidence interval (CI) 1.51-14.60, p=0.011) and preterm birth (OR=3.74, 95% CI 1.20-11.67, p=0.040). Neonates born to mothers with severe COVID-19 had significantly higher odds of testing PCR-positive (OR=27.00, 95% CI 6.86-106.30, p<0.001), requiring NICU admission (OR=14.33, 95% CI 4.15-49.55, p<0.001), and having lower APGAR scores (OR=0.06, 95% CI 0.02-0.25, p<0.001). Severe disease was also associated with lower neonatal birth weight (p=0.009) and prolonged maternal and neonatal hospitalization (p<0.001 for both).
conclusionsIn this Lebanese cohort, maternal COVID-19 severity demonstrated strong associations with adverse obstetrical and neonatal outcomes. The markedly elevated risks, particularly for neonatal infection and NICU admission, underscore the need for vigilant management of pregnant women with COVID-19. However, the observational design, single-center setting, and small number of severe cases necessitate cautious interpretation. These findings highlight the critical importance of preventative strategies, including vaccination, and call for larger, prospective regional studies.
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