Evidence map›Paper›PMID 41450336›Full record

ArticleMaterials today. Bio2025

ROS/pH dynamically responsive injectable hydrogel ameliorates disc degeneration by re-establishing the oxidative stress microenvironment.

Jia-Jie Lu, Yi-Tuo Chen, Qi-Chen Zhang, Xian Wang, Guang-Cheng Yuan, Yu-Kai Huang, Tao Wu, Jian Dong, Li-Bo Jiang, Xi-Lei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Jie LuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yi-Tuo ChenDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qi-Chen ZhangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xian WangShanghai Fengxian District Central Hospital, No. 6600, Nanfeng Highway, Fengxian District, Shanghai, 201499, China.
Guang-Cheng YuanDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yu-Kai HuangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Tao WuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jian DongDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Li-Bo JiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xi-Lei LiDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD) stands as a predominant cause of low back pain (LBP). The excessive accumulation of reactive oxygen species (ROS) represents a crucial pathophysiological mechanism involved in IVDD, which triggers oxidative stress in the microenvironment, resulting in apoptosis, inflammation, and metabolic imbalance of extracellular matrix (ECM). Here, we ingeniously devised an injectable hydrogel (CMC-PBA/ODEX/HMP@Lut) consisting of phenylboronic acid-modified carboxymethyl chitosan (CMC-PBA), oxidized dextran (ODEX), MnO

Indexed as

Extracellular matrixInflammationIntervertebral disc degenerationMnO2ROS/pH dual-responsive

Identifiers

PMID41450336
PMCPMC12731294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.