ArticleJournal of cosmetic dermatology2026
An Innovative Serum With Retinol, Hydroxypinacolone Retinoate, Peptides, and Silybin Improves Mild Photoaged Facial Skin in Middle-Aged Chinese Women.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Nanoliposome Platform Co-Delivery of Hydroxypinacolone Retinoate and Carnosine for Enhanced Epidermal/Dermal Delivery and Multi-Functional Anti-Aging Efficacy.Pharmaceutics · 2026Article
- An Innovative Serum With Retinol, Hydroxypinacolone Retinoate, Peptides, and Silybin Improves Mild Photoaged Facial Skin in Middle-Aged Chinese Women.Journal of cosmetic dermatology · 2026Article
- Advances in research on the mechanisms of anti-inflammation of silybin: a review.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundRetinoids are effective anti-aging agents, but their use is often limited by irritation, particularly in Asian skin. Hydroxypinacolone retinoate (HPR), a novel retinoid ester, offers similar benefits with reduced irritation, yet its combined use with retinol remains poorly characterized. Additionally, the integration of peptides and botanical antioxidants like silybin into retinoid-based regimens lacks mechanistic and clinical evidence.
aimsTo investigate the molecular mechanisms and clinical efficacy of a novel serum containing retinol, HPR, peptides, and silybin in improving mild photoaged facial skin in Chinese women.
methodsMechanistic effects were investigated using transcriptomic profiling in a keratinocyte-fibroblast co-culture and protein expression analysis in UV-exposed ex vivo skin models. Clinical efficacy was assessed in an 8-week study in middle-aged Chinese women with mild photoaging.
resultsRetinol + HPR synergistically activated TGF-β/Smad signaling and enhanced extracellular matrix gene expression compared with retinol alone. The addition of silybin further promoted collagen and elastin synthesis. Clinically, the serum significantly improved wrinkles, elasticity, hydration, barrier function, and pigmentation with excellent tolerability.
conclusionsThis multi-active serum demonstrates a synergistic, well-tolerated anti-aging effect. To our knowledge, this work provides an integrated molecular-to-clinical evaluation of a retinol-HPR-peptide-silybin combination, supporting its potential as a potent yet gentle anti-aging option for sensitive skin.
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