ArticleCNS neuroscience & therapeutics2025
Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Association of Reproductive Factors and Postmenopausal Sex Hormones With Cognitive Impairment in Postmenopausal Women With Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Comparative Peripheral Blood Transcriptomic Profiles in Parkinson's Disease and Restless Legs Syndrome: An Exploratory Between-Cohort Analysis.International journal of molecular sciences · 2026Article
- Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.Brain communications · 2026Article
- Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression.CNS neuroscience & therapeutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThe pathophysiology and neural substrates of depression in Parkinson's disease remain unclear. It has been associated with dysregulation of the monoaminergic systems. Furthermore, functional abnormalities within the mesolimbic-basal ganglia reward circuit may be involved in the pathogenesis of Parkinson's disease-related depression.
objectivesWe aimed to investigate monoaminergic deficits and the corresponding changes within the striatum-mesolimbic circuitry in patients with Parkinson's disease and depression.
methodsThis study included eight depressed and 18 non-depressed patients with Parkinson's disease and 28 matched healthy controls. We simultaneously obtained
resultsPatients who were depressed exhibited greater monoaminergic deficits in the anterior dorsal and ventral putamen and the nucleus-accumbens than non-depressed patients did. Depression severity was negatively correlated with standardized uptake value ratio in the anterior ventral putamen and the nucleus-accumbens of patients with Parkinson's disease. Compared with non-depressed patients, higher functional connectivity was noted within the striatum-mesolimbic circuit in depressed patients.
conclusionsIn depressed Parkinson's disease patients, monoaminergic deficits are present alongside abnormally increased connectivity within the striatum-mesolimbic circuitry, highlighting this pathway as a potential target for treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.