Evidence map›Paper›PMID 41449918›Full record

SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Anticoagulation Timing After Stroke in Atrial Fibrillation: Evidence from a Systematic Review and Meta-Analysis.

Mostafa Hossam El Din Moawad, Suhel Batarseh, Abdelaziz A Awad, Raghad Amro, Ahmed Farid Gadelmawla, Omar A Kaoud, Dina Essam Abo-Elnour, Muhammad Daoud Tariq, Osama Omar Ballut, Judy Ahmed Abdullah and 8 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mostafa Hossam El Din MoawadAlexandria Main University Hospital, Alexandria, Egypt.
Suhel BatarsehFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Abdelaziz A AwadFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Raghad AmroFaculty of Medicine, Mutah University, Al-Karak, Jordan.
Ahmed Farid GadelmawlaFaculty of Medicine, Menoufia University, Menoufia, Egypt.ORCID 0000-0002-5802-2291
Omar A KaoudFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID 0000-0001-8835-2841
Dina Essam Abo-ElnourFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Muhammad Daoud TariqDepartment of Internal Medicine, Foundation University Medical College, Islamabad, Pakistan.
Osama Omar BallutFaculty of Medicine, Cairo University, Cairo, Egypt.
Judy Ahmed AbdullahFaculty of Medicine, New Giza University, Giza, Egypt.
Ammar MektebiFaculty of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.
Ibrahim SeragFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed AlattarKing Abdullah Medical City, Makkah, Saudi Arabia.
Ibraheem M AlkhawaldehFaculty of Medicine, Mutah University, Al-Karak, Jordan.
Hamza A Abdul-HafezDepartment of Medicine, An-Najah National University, Nablus, Palestine.ORCID 0009-0003-6089-240X
Mohamed AbouzidDepartment of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Mohamed O MohamedInstitute of Health Informatics, University College London, London, UK.
Osama BishtEvangelisches Herzzentrum Coswig, Coswig (Anhalt), Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundThe optimal timing for initiating oral anticoagulation (OAC) after acute ischemic stroke in patients with atrial fibrillation (AF) remains a critical clinical dilemma. Early anticoagulation may lower recurrent ischemic stroke risk but could raise hemorrhagic transformation risk, and current guidelines are conflicting. This meta-analysis examined the impact of early versus late initiation of anticoagulation on clinical outcomes-recurrent stroke, intracranial haemorrhage, Bleeding, mortality, transient ischemic attack (TIA), and thrombosis-in AF-related ischemic stroke.MethodsFollowing PRISMA guidelines, we conducted a systematic review and meta-analysis of observational and experimental studies that compared early and late anticoagulation; seventeen studies met inclusion criteria.ResultsEarly anticoagulation was associated with a significantly lower risk of recurrent ischemic stroke (OR = 0.72, 95% CI [0.55-0.96],

Indexed as

AnticoagulantsAtrial FibrillationStrokeHumansTime FactorsAnticoagulantsanticoagulationatrial fibrillationhemorrhagic transformationischemic strokemeta-analysisstroke recurrence

Identifiers

PMID41449918
PMCPMC12745514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.