Evidence map›Paper›PMID 41449898›Full record

ArticleBJPsych open2025

Overt and covert processing of self-relevance information in dissociative identity disorder: controlled fMRI study.

Aikaterini I Strouza, Andrew J Lawrence, Lora I Dimitrova, Eline M Vissia, Sima Chalavi, Dick J Veltman, Antje A T S Reinders

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Article in BJPsych open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Aikaterini I StrouzaDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0002-6030-1476
Andrew J LawrenceDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Lora I DimitrovaDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Eline M VissiaHeelzorg, Centre for Psychotrauma, Zwolle, The Netherlands.
Sima ChalaviMovement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, VU University Amsterdam, Amsterdam, The Netherlands.
Antje A T S ReindersDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0002-7987-1532

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDissociative identity disorder (DID) manifests with distinct trauma-avoidant and trauma-related identity states. Overtly conscious trauma-related knowledge processing is identity state-dependent. Previous research on covertly subconscious knowledge processing in DID lacks subject-specific trauma-related stimuli.

aimsOur controlled functional magnetic resonance imaging (fMRI) study explored neural and behavioural differences of overt and covert knowledge processing of individualised self-relevant words in DID.

methodBehavioural data were gathered while 56 participants underwent task-based fMRI: 14 with DID, 14 DID simulators and a paired control group of 14 healthy controls and 14 participants with post-traumatic stress disorder. Individuals with DID and simulators participated in a trauma-avoidant and a trauma-related identity state. Reaction times and brain activation following overtly and covertly presented individualised words were statistically analysed.

resultsBehavioural analyses showed a main effect of consciousness (

conclusionsThe present study showed increased cognitive control during overt self-relevant knowledge processing in the trauma-avoidant identity state of DID, in line with previous research. The slower reaction times and increased frontoparietal activation shown in individuals with diagnosed DID, as compared with both control groups, support the notion of cognitive avoidance of trauma-related information in DID and further reinforce the authenticity of DID experiences.

Indexed as

Dissociationpost-traumatic stress disorderself-relevance processingsimulationtrauma

Identifiers

PMID41449898
PMCPMC12835690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.