ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Potent and Long-Lasting Immunogenicity Generated by LNP-mRNA gE Antigen Against Varicella Zoster Virus via an AI-Assisted Pipeline.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Herpes zoster (HZ), caused by varicella zoster virus (VZV) reactivation commonly in elderly/immuno-compromised individuals, leads to tremendous social burden. Despite approved vaccines, there is an urgent need for longer-lasting and more effective HZ vaccines. This study designs a novel mRNA-LNP vaccine targeting VZV glycoprotein E (gE), with the assistance of AI technology, achieving effective and enduring prevention against VZV infection with favorable safety. From numerous empirically designed antigen sequences, AI-based screening identifies promising candidate variants, which are systematically evaluated based on their humoral and cellular immune responses in BALB/c mice. The study further explores the underlying correlation between the cellular localization and immunogenicity of the vaccine candidates and screens 5'UTR elements affecting mRNA expression. A 4-week administration interval and immunogenicity are subsequently validated via detection of gE-specific IgG antibodies and CD4
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