ArticleArthritis care & research2026
COVID-19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans.
Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
objectiveSeveral case reports have proposed a potential association between COVID-19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID-19 vaccination in US veterans who developed new-onset IIM compared to those without new-onset IIM.
methodsFor this case-control study, new-onset incident cases of IIM were veterans enrolled in the Veterans Health Administration (VHA) with at least two IIM International Classification of Diseases (ICD) codes, at least one year of VHA enrollment before the first IIM ICD code, and chart review confirming incident IIM. Each IIM incident case was matched 1:5 to control patients without IIM who had similar age, sex, race, specialty clinic visits for the first IIM diagnostic code, and year of specialty clinic visit.
resultsThe 89 patients with new-onset incident IIM identified were matched to 445 controls without IIM. Seven (7.9%) case patients and 29 (6.5%) control patients received their first COVID-19 vaccination within 30 days before the index date (odds ratio [OR] 1.22, P = 0.643; adjusted OR 1.12, P = 0.657), and 11 (12.4%) case patients and 68 (15.3%) control patients received their first vaccination within 90 days of the index date (OR 0.78, P = 0.479; adjusted OR 0.74, P = 0.402). Multiple other comparisons also failed to identify a statistically significant association between COVID-19 vaccination and IIM.
conclusionThis study is the first to compare the risk of developing myositis after receiving COVID-19 vaccination to that of a control population. This comparison did not identify a risk for developing IIM after COVID-19 vaccination.
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