ArticleEuropean journal of medical research2025
Effects of pelvic floor electrical stimulation with an implantable device at different frequencies on stress urinary incontinence in rats.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMost pelvic floor electrical stimulation (PFES) is intravaginal, with little research on how stimulation frequencies affect stress urinary incontinence (SUI) treatment. This study aimed to investigate the effects of different stimulation frequencies on improving SUI through PFES using an implantable PFES device in rats.
methodsA miniature, implantable, wireless PFES device (NuStim) was used to stimulate the pelvic floor muscles of 24 female Sprague-Dawley rats. All animals underwent vaginal distension (VD) to mimic postpartum SUI. PFES was applied at four frequencies (6 Hz, 15 Hz, 30 Hz and 50 Hz) to four experimental groups for 2 consecutive weeks. Multiple cystometrograms (CMGs) were performed to measure leak point pressure (LPP) and maximal bladder capacity (MBC).
resultsVD-induced SUI significantly reduced the LPP to 21.1 ± 2.5 cmH
conclusionsThis study demonstrated that different PFES frequencies could all promote the recovery of urinary control function, with no significant differences in therapeutic effects. However, further randomized controlled studies were needed to assess additional frequencies and the long-term efficacy of PFES.
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