ArticleBMC psychiatry2025
Shared but distinct functional connectome profiles underlying rumination in depressed and healthy individuals.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRumination—a passive, repetitive focus on negative thoughts and emotions—is a key risk factor for the onset and recurrence of depression. While prior studies have linked rumination to altered functional connectivity (FC) in brain networks, most relied on self-reported measures and resting-state fMRI, potentially missing key neural dynamics during active ruminative states.
methodsWe recruited 43 patients with major depressive disorder (MDD) and 42 matched healthy controls (HCs). Using a validated rumination state task (RST), we induced active rumination and distraction states during fMRI scanning. We constructed whole-brain functional connectomes and examined both FC patterns and a graph-theoretical feature (eigenvector centrality) across conditions. We also examined associations between the graph-theoretical feature and depressive symptom severity.
resultsBoth MDD patients and HCs exhibited enhanced FC between the core and medial temporal lobe (MTL) subsystems of the default mode network (DMN) during rumination compared to distraction. However, edge-level analyses revealed group differences: HCs showed greater FC increases between the ventral attention network (VAN) and the DMN-MTL subsystem. We found a significant interaction effect regarding eigenvector centrality in a VAN node (Par_Med_4_R). During rumination, patients with MDD exhibited elevated eigenvector centrality compared to distraction, whereas HCs did not. This elevation correlated positively with depression severity.
conclusionsThis study provides the first comprehensive characterization of the active rumination connectome in MDD. Results highlight a shared DMN mechanism and a VAN-specific topological alteration in MDD, supporting the theory that excessive automatic constraints from attentional systems may drive maladaptive rumination. CLINICAL TRIAL NUMBER: Not applicable
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.