ArticleBMC medical imaging2025
Impaired left ventricular global longitudinal strain is associated with diastolic dysfunction in obstructive hypertrophic cardiomyopathy.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectivesLeft ventricular global longitudinal strain (LV-GLS) provides additional insight into subtle myocardial contractile impairment in hypertrophic cardiomyopathy (HCM). However, its clinical value in evaluating diastolic dysfunction remains insufficiently characterized. The primary objective of this study was to investigate the association between LV-GLS and the severity of diastolic dysfunction in symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients with preserved LVEF, and to assess the potential utility of LV-GLS for grading diastolic dysfunction in this patient cohort.
methodsA total of 145 consecutive symptomatic HOCM patients were enrolled and classified into diastolic dysfunction grade I or grade II according to the ASE-recommended algorithm. Multivariate regression analysis was performed to identify independent factors associated with the severity of diastolic dysfunction.
resultsAmong the 145 patients, 109 (75.2%) had grade II and 36 (24.8%) had grade I diastolic dysfunction. Grade II dysfunction was more common among females. Greater myocardial wall thickness, elevated BNP levels, and reduced LV-GLS were independently associated with more advanced diastolic dysfunction, irrespective of loading conditions and preserved LVEF. Receiver operating characteristic analysis demonstrated that LV-GLS effectively discriminated diastolic dysfunction grade, with an area under the curve (AUC) of 0.728 (p = 0.001).
conclusionsReduced LV-GLS was independently associated with more advanced diastolic dysfunction in symptomatic HOCM patients with preserved LVEF. LV-GLS provides incremental value for grading diastolic dysfunction and could improve risk stratification for heart failure with preserved ejection fraction in this population. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.