Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2026
A randomized clinical trial of ammonia-free silver fluoride for treating cavitated dentine caries in primary teeth: adverse effects, short-term discolouration, and patient-reported outcomes.
Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of ammonia-free silver fluoride application on the resin-dentin interface subjected to an in situ cariogenic challenge.Clinical oral investigations · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmmonia-free silver fluoride formulations have been developed to reduce unpleasant taste and potential mucosal irritation associated with conventional silver diamine fluoride (SDF) products.
aimTo compare RIVA STAR AQUA and RIVA STAR in terms of the presence of adverse effects, short-term caries lesion discolouration, and child-reported discomfort during treatment.
designIn this randomized clinical trial, 4-10-year-old children with cavitated caries lesions exposing dentine in primary molars (ICDAS 5-6) were recruited from public schools in João Pessoa and Guarabira, Brazil. Participants were allocated to receive either RIVA STAR AQUA (test) or RIVA STAR (control). Adverse effects (soft-tissue ulceration, allergy, nausea/vomiting, bad taste, tooth pain/sensitivity, pigmentation, esthetic concerns) were assessed immediately and after 1 week. Child-reported discomfort was recorded using the Wong-Baker faces scale. Data were analyzed using t tests, Mann-Whitney U, chi-square, and ordinal logistic regression (α = 5%).
results85 children (155 teeth) were re-examined after 1 week (3.4% loss to follow-up). Overall adverse effects occurred in 74.8% of teeth, with no difference in total incidence between groups. RIVA STAR AQUA resulted in fewer reports of bad taste and soft-tissue ulceration. Discomfort scores were low with no significant between-group difference (OR = 0.52; p = 0.076). Dark discolouration was observed in 87.1% of teeth after 1 week.
conclusionRIVA STAR AQUA may be a suitable alternative to RIVA STAR with no differences in the overall presence of adverse effects and fewer taste-related complaints and mucosal ulcerations, without increasing discomfort. Long-term studies are warranted to assess its caries lesion arrest effectiveness. CLINICAL
trial registrationReBEC RBR-2qz7vwt.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.