Evidence map›Paper›PMID 41449272›Full record

ArticleJournal of natural medicines2026

Chemical characterization and ATP-citrate lyase inhibitory activity study of clerodane diterpenoids from Tinospora crispa.

Jin-Qiu You, Yun-Qi Jin, Chun-Yang Zhang

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Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jin-Qiu YouDepartment of Pharmacy, Suzhou Dushu Lake Hospital, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, 9 Chongwen Road, Suzhou, 215123, Jiangsu, People's Republic of China. youjinqiu1104@163.com.ORCID http://orcid.org/0009-0008-1901-8581
Yun-Qi JinShanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Chun-Yang ZhangDepartment of Pharmacy, Suzhou Dushu Lake Hospital, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, 9 Chongwen Road, Suzhou, 215123, Jiangsu, People's Republic of China.

Funding

Suzhou Science and Education to revitalize Health Youth Science and Technology Project QNXM2024028
6 · The paper itself

Abstract

Three previously undescribed clerodane diterpenoids, named as tincrispoids A‒C (1‒3), accompanied by nine known analogues (4‒12), were isolated from the stems of Tinospora crispa. Structural determination, including assignment of absolute configurations, was achieved through a combination of spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) computations. The heterocyclic skeletons of the isolates exhibit remarkable structural diversity, comprising 6/6/6- (1 and 5), 6/6- (2, 3, and 7‒9), 6/6/5- (4), 6/5/6/6- (6), and 6/5/6- (10‒12) fused ring systems. Compound 4 showed moderate inhibitory effect on ATP-citrate lyase (ACLY). Molecular docking simulations revealed the specific interaction between compound 4 and ACLY.

Indexed as

ATP Citrate (pro-S)-LyaseDiterpenes, ClerodaneEnzyme InhibitorsTinosporaMolecular Docking SimulationMolecular StructurePlant StemsATP Citrate (pro-S)-LyaseDiterpenes, ClerodaneEnzyme InhibitorsATP-citrate lyaseClerodane diterpenoidsMolecular dockingTinospora crispa

Identifiers

PMID41449272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.