ArticleGeroScience2026
High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth.The Journal of physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The ability to suppress irrelevant or distracting inputs that interfere with goal-driven behavior is known to decline with increasing age. Although noninvasive stimulation of the motor cortices has been shown to modulate age-related changes in motor activity, the findings remain preliminary, and it is unknown whether this effect extends beyond the motor cortex. In this study, 125 healthy adults, categorized into young (20-35 years) and older groups (55-72 years) underwent three visits (i.e., anodal, cathodal, and sham). During each visit, they received 20 min of high-definition transcranial direct current stimulation (HD-tDCS) applied to their left primary motor cortex (M1) and completed a flanker task during high-density magnetoencephalography (MEG). Statistically significant oscillatory responses were imaged and analyzed using voxel-wise, whole-brain, and point of stimulation approaches. Our results showed increased gamma flanker interference effects within the contralateral M1 in older relative to younger adults following anodal stimulation, and after anodal compared to cathodal HD-tDCS in older adults. We also found polarity-based differences in beta and gamma M1-prefrontal connectivity as a function of age group. Critically, these data indicate distinct spectrally- and polarity-dependent effects of M1 HD-tDCS on the local and network-level neurophysiological responses serving motor performance in young versus older healthy adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.