Evidence map›Paper›PMID 41449231›Full record

ArticleScientific reports2025

Gestational physical exercise prevents early-life behavioral impairments in the offspring of a rat model of attention deficit hyperactivity disorder.

Andrea Tosta, Ariene S Fonseca, Debora Jardim Messeder, Priscila Siqueira, Sérgio T Ferreira, Mychael V Lourenco, Pablo Pandolfo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea TostaProgram of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi, Brazil.
Ariene S FonsecaInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Debora Jardim MessederProgram of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi, Brazil.
Priscila SiqueiraProgram of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi, Brazil.
Sérgio T FerreiraInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mychael V LourencoInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pablo PandolfoProgram of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi, Brazil. pablopandolfo@id.uff.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308050/2022-3Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 26/201.430/2021Instituto Serrapilheira R-2012-37967
6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) is a developmental condition characterized by symptoms of inattention, hyperactivity, and impulsivity. Spontaneously hypertensive rats (SHRs) comprise an ADHD rodent model that exhibits behavioral impairments recapitulating phenotypes observed in humans. SHRs further develop dopaminergic hypofunction in frontostriatal circuits and an imbalance in dopamine and norepinephrine systems. Maternal physical exercise, such as swimming, during pregnancy was shown to enhance offspring angiogenesis and neurogenesis, and to improve memory in rodents. Herein we determined the impact of gestational swimming on behavioral and dopaminergic parameters in childhood (1-2 week-old rats) and adolescence (4-5 week-old rats) of SHR and Wistar Kyoto rats (WKYs), used as a control group. The results showed that gestational swimming prevented neurodevelopmental impairments in behavior, assessed by the righting reflex and olfactory recognition tests, in the offspring. Furthermore, during adolescence, SHRs from exercised dams exhibited reduced novelty-seeking behavior, an important behavioral trait during this developmental period. Finally, D

Indexed as

Attention Deficit Disorder with HyperactivityBehavior, AnimalPhysical Conditioning, AnimalPrenatal Exposure Delayed EffectsAnimalsDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsFemaleMalePregnancyRatsRats, Inbred SHRRats, Inbred WKYReceptors, Dopamine D2SwimmingDopamineDopamine Plasma Membrane Transport ProteinsReceptors, Dopamine D2ADHDAdolescenceDopamine receptorGestational swimmingNeurodevelopmentNovelty-seeking behaviorPrefrontal cortex

Identifiers

PMID41449231
PMCPMC12852695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.