Evidence map›Paper›PMID 41449216›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Cutaneous/subcutaneous RREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasm-two cases expanding the anatomical spectrum of an emerging entity.

Miroslav Důra, Martina Baněčková, Tomáš Rozkoš, Michal Michal, Michael Michal, Liubov Kastnerová

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Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Miroslav DůraBioptical Laboratory, Ltd., Pilsen, Czech Republic. dura@biopticka.cz.
Martina BaněčkováBioptical Laboratory, Ltd., Pilsen, Czech Republic.
Tomáš RozkošThe Fingerland Department of Pathology, Charles University Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Michal MichalBioptical Laboratory, Ltd., Pilsen, Czech Republic.
Michael MichalBioptical Laboratory, Ltd., Pilsen, Czech Republic.
Liubov KastnerováBioptical Laboratory, Ltd., Pilsen, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasm is a recently recognized tumor so far mostly described in the head and neck area and in the mediastinum. At least some of these neoplasms are potentially related to ectomesenchymal chondromyxoid tumor of the tongue since they share an identical gene fusion and overlapping morphological features in some cases. Herein we describe for the first time two cases with RREB1::MRTFB fusion located in the skin and subcutis. The cases occurred in 36-year-old male with a cutaneous mass on the nose and in 65-year-old woman with a large subcutaneous mass involving the lower leg. Histopathologically, both cases consisted of bland ovoid cells in a myxoid stroma. Immunohistochemically, one of the two cases showed diffuse S100 positivity. RREB1::MRTFB fusion was confirmed in both cases. In summary, the two reported cases expand the anatomical spectrum and improve our understanding of this rare emerging entity.

Indexed as

Biomarkers, TumorDNA-Binding ProteinsSkin NeoplasmsTranscription FactorsAdultAgedFemaleGene FusionHumansImmunohistochemistryMaleBiomarkers, TumorDNA-Binding ProteinsRREB1 protein, humanTranscription FactorsEctomesenchymal chondromyxoid tumorExtra-glossal mesenchymal neoplasmRREB1::MRTFB fusion

Identifiers

PMID41449216
PMCPMC13264556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.