ArticleThe clinical respiratory journal2025
Association Between Respiratory Viral Infection and Peripheral T Lymphocyte Subsets in Elderly Patients With Acute Exacerbation of Bronchiectasis.
Article in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association Between Respiratory Viral Infection and Peripheral T Lymphocyte Subsets in Elderly Patients With Acute Exacerbation of Bronchiectasis.The clinical respiratory journal · 2025Article
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7 authors.
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Abstract
backgroundRespiratory viral infections are increasingly recognized as important triggers of acute exacerbations in bronchiectasis (AEB); the virological profiles and immunological mechanisms in elderly patients remain poorly characterized.
methodsA prospective cohort of 102 elderly bronchiectasis patients was followed for 12 months. Upon AEB occurrence, nasopharyngeal swabs were obtained for multiplex fluorescence quantitative PCR detection of eight respiratory viruses, while peripheral blood samples were analyzed for T lymphocyte subsets by flow cytometry. Clinical characteristics, inflammatory markers, and T cell subsets were compared between virus-positive and virus-negative groups at first AEB; ROC curve analysis evaluated the predictive value of T cell subsets for viral infection.
resultsA total of 93 AEB episodes were captured from 68 patients during 12-month follow-up, with viruses detected in 54.8% (51 of 93) of episodes, influenza virus being the most common pathogen (24 of 51, 47.1%). Compared with the virus-negative group, the virus-positive group showed higher IL-6 and TNF-α and lower CRP and WBC levels (p < 0.05), higher sputum culture positivity with Haemophilus influenzae predominating, along with increased use of intravenous antibiotics and respiratory support, while quality of life, pulmonary function, and oxygenation remained comparable. The virus-positive group showed lower CD4
conclusionsViral infections are frequent in elderly bronchiectasis patients with AEB and are characterized by reduced CD4
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