Evidence map›Paper›PMID 41448829›Full record

ArticleBritish journal of haematology2026

Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge.

Adriana Balduzzi, Maria Grazia Valsecchi, Thai Hoa Tran, Jan Zuna, Veronica Leoni, Gunnar Cario, Grazia Fazio, Virginie Gandemer, Sarah K Tasian, Inge M van der Sluis and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. DifferentialHemaSphere · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Adriana BalduzziDepartment of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Maria Grazia ValsecchiSchool of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Thai Hoa TranDivision of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec, Canada.ORCID https://orcid.org/0000-0002-8712-6233
Jan ZunaCLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.
Veronica LeoniDepartment of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Gunnar CarioDepartment of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Kiel, Germany.
Grazia FazioSchool of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Virginie GandemerDepartment of Pediatric Hematology and Oncology, CHU Hôpital Sud, Rennes, France.ORCID https://orcid.org/0000-0002-4991-233X
Sarah K TasianDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Inge M van der SluisPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Nicolò PeccatoriDepartment of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Rosanna ParasoleDepartment of Oncology, Hematology and Cellular Therapy, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Stefania MonterisiClinical Trials and Phase I Unit, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Mignon L LohSeattle Children's Hospital, Seattle, Washington, USA.
Meenakshi DevidasDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-1099-3478
Stephen P HungerDepartment of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
John A KairallaDepartment of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA.
Paola De LorenzoTettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Lewis B SilvermanDivision of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA.
Andrea BiondiTettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Multispecific targeting incorporating cytokine receptor pathways in high risk pediatric acute leukemias to improve durability of adoptive cell therapy-induced remissionsU01CA232486 · NCI · UNIVERSITY OF COLORADO DENVER · PI FRY, TERRY J., TASIAN, SARAH KATHLEEN · 2018 to 2018
$4.0M
Towards rational design of combination therapeutic targetsU01CA243072 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI TAN, KAI, TASIAN, SARAH KATHLEEN · 2020 to 2024
$2.6M
Agentura Pro Zdravotnický Výzkum České Republiky NW25-03-00276Deutsche Krebshilfe 70112958Ministero della SaluteNCI NIH HHS 1U01CA232486NCI NIH HHS 1U01CA243072NCI NIH HHS U01 CA232486NCI NIH HHS U01 CA243072NCI NIH HHS U10 CA180886NCI NIH HHS U10CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U10CA180899
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

immunotherapyintercurrent eventslong‐term outcomesminimal residual diseasepaediatric Ph+ALLtyrosine kinase inhibitors

Identifiers

PMID41448829
PMCPMC12995522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.