Evidence map›Paper›PMID 41448792›Full record

ArticleBMJ open respiratory research2025

Evaluation of biomarkers sTREM-1, procalcitonin and C reactive protein in the diagnosis of pleural infection.

Vanessa Adelia Alvarenga, Lisete Ribeiro Teixeira, Roberta Karla Barbosa Sales, Philippe Figueiredo Braga Colares, Carlos Sergio Rocha Silva, Evaldo Marchi, Milena Marques Pagliarelli Acencio

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Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Vanessa Adelia AlvarengaPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Lisete Ribeiro TeixeiraPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Roberta Karla Barbosa SalesPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Philippe Figueiredo Braga ColaresPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Carlos Sergio Rocha SilvaPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Evaldo MarchiJundiai Medicine College, Jundiai, Brazil.
Milena Marques Pagliarelli AcencioPulmonary Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil milena.acencio@hc.fm.usp.br.ORCID http://orcid.org/0000-0002-4624-1235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of complicated parapneumonic pleural effusion (CPPE), empyema and uncomplicated parapneumonic pleural effusion (UPPE) is vital in therapeutic management.

objectiveTo measure the pleural fluid concentrations of soluble triggering receptor expressed on myeloid cell-1 (sTREM-1), procalcitonin (PCT) and C reactive protein (CRP) to provide information for diagnosing and discriminating between CPPE and UPPE.

methodsRetrospective data analysis from February 2016 to December 2017, focused on pleural fluid analysis of patients with infectious (PPE, empyema and tuberculosis) and non-infectious (malignant and transudates) effusions.

resultsOver 224 pleural fluid samples collected, 29 were empyema, 48 CPPE, 31 UPPE, 35 tuberculous, 47 malignant and 34 transudates. The levels of sTREM-1 and PCT were significantly higher in empyema (3658±1474 and 1704±1027) and CPPE (2651±1058 and 841±667) and lower in transudates (p<0.001). CRP levels were significantly higher in empyema (88.8±61.5) and CPPE (83.8±42.6) than in other groups (p<0.001), with no difference between them.

conclusionThe study demonstrated higher sTREM-1, PCT and CRP levels in empyema and CPPE and lower levels in transudates. Both sTREM-1 and CRP showed a higher than 70% diagnostic accuracy between infectious and non-infectious pleural effusions and between CPPE and UPPE; however, not superior to LDH pleural fluid levels.

Indexed as

C-Reactive ProteinEmpyema, PleuralPleural EffusionProcalcitoninTriggering Receptor Expressed on Myeloid Cells-1AdultAgedAged, 80 and overBiomarkersDiagnosis, DifferentialExudates and TransudatesFemaleHumansMaleMiddle AgedRetrospective StudiesBiomarkersC-Reactive ProteinProcalcitoninTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1EmpyemaPleural DiseaseRespiratory Infection

Identifiers

PMID41448792
PMCPMC12742160

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