Evidence map›Paper›PMID 41448754›Full record

ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2025

[Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].

Xiaoyan Shen, Xinlong Zhang, Xiongjie Lou, Hui Gu, Xiongheng Bian, Hongkui Zhong, Yuhua Zhao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaoyan ShenSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Xinlong ZhangSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Xiongjie LouSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Hui GuSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Xiongheng BianSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Hongkui ZhongSchool of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Yuhua ZhaoYancheng Tongzhou Orthopedic Hospital, Yancheng, Jiangsu 224002, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraspinal microstimulation (ISMS) is a rehabilitation technology that activates muscle movement by electrically stimulating the spinal cord, thereby restoring the function of paralyzed limbs. In this study, a fuzzy logic-controlled self-tuning proportional-integral-derivative (PID) algorithm was adopted. By simultaneously adjusting three key electrical stimulation parameters-amplitude, pulse width, and frequency of the pulse signal-the distal locomotor central pattern generator (CPG) in rats with spinal cord injury (SCI) was activated, realizing real-time control of hindlimb ankle joint movement in paralyzed rats. To verify the control performance of the intraspinal microstimulation system, animal experiments were conducted. Statistical results showed that the root mean square error (RMSE) of joint angle tracking was 2.50°, and the normalized root mean square error (NRMSE) was 5.78%. The results indicate that the ankle joint of the paralyzed hindlimb in SCI rats can move according to the preset angle trajectory through single-electrode intraspinal electrical stimulation.

Indexed as

Ankle JointCentral Pattern GeneratorsElectric Stimulation TherapyParalysisSpinal Cord InjuriesAlgorithmsAnimalsElectric StimulationFuzzy LogicHindlimbLower ExtremityMaleMovementRatsSpinal CordCentral pattern generatorControl strategyIntraspinal microstimulation

Identifiers

PMID41448754
PMCPMC12744980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.