Evidence map›Paper›PMID 41448674›Full record

ArticleBMJ open2025

Association between body roundness index and kidney stone risk in Chinese adults: an ultrasound-based cross-sectional study.

Wei Zhang, Tianchi Hua, Shengqi Zheng, Shangchun Fei, Yifan Li, Qibing Fan

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Wei Zhang *Urology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China.ORCID http://orcid.org/0009-0007-7823-2716
Tianchi Hua *Urology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China.ORCID http://orcid.org/0000-0001-7196-0728
Shengqi ZhengUrology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China.
Shangchun FeiUrology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China.
Yifan LiUrology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China fanfan_20020315@163.com 092107@yzu.edu.cn.
Qibing FanUrology, Yangzhou University Medical college Affiliated Hospital, Yangzhong, Jiangsu, China fanfan_20020315@163.com 092107@yzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity is a key risk factor for kidney stones (KS). The body roundness index (BRI) is a newer measure for assessing body fat distribution. Studies in Western populations have linked BRI to KS risk, but no such research has been conducted in Asian populations. This study aimed to examine the association between BRI and KS in Chinese adults. MATERIALS AND

methodsThis cross-sectional study included 78 386 Chinese adults who underwent abdominal ultrasound examination. Data on demographic characteristics, clinical history and laboratory parameters were collected. The diagnosis of KS was based on the ultrasound findings. Multivariable logistic regression examined the association between the BRI and KS risk. The analysis incorporated subgroup analyses, dose-response relationship assessment and mediation analysis.

resultsMultivariable-adjusted logistic regression analyses revealed that the BRI was significantly positively correlated with KS risks in both genders, with a more pronounced effect observed in males (OR 1.16, 95% CI 1.12 to 1.20) compared with females (OR 1.11, 95% CI 1.04 to 1.20). Participants in the highest BRI tertile had a 47% and 23% higher KS risk in males and a 23% higher KS risk in females, respectively, compared with the lowest tertile. Dose-response analysis showed a non-linear relationship between BRI and KS risk in both males and females. Mediation analysis indicated that low-density lipoprotein cholesterol accounted for 7.2% of the association in females, whereas hypertension (14.8%) and uric acid (12.5%) were the primary mediating factors in males. Subgroup analyses confirmed that the association was modified by age and diabetes in females and by diabetes in males.

conclusionThe findings demonstrate a significant association between elevated BRI and increased KS risk, underscoring the necessity of implementing gender-specific strategies and considering mediating factors in KS prevention.

Indexed as

Kidney CalculiObesityAdultAgedBody Mass IndexChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansLogistic ModelsMaleMiddle AgedRisk FactorsSex FactorsUltrasonographyCross-Sectional StudiesObesityUrolithiasis

Identifiers

PMID41448674
PMCPMC12742156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.