ArticleCell2025
Stimulant medications affect arousal and reward, not attention networks.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Green space is associated with better directed attention and higher crystallized intelligence in middle childhood: Evidence from the ABCD study.Environment international · 2026Article
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Subjective sleepiness and objective sleep propensity in adults with attention-deficit/hyperactivity disorder referred for multiple sleep latency testing.Frontiers in psychiatry · 2026Article
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025Article
- Motion impact score for detecting spurious brain-behavior associations.Nature communications · 2025Article
- Frame-wise multi-echo distortion correction for superior functional MRI.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
- Update of
Authors and funding
37 authors.
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA. Electronic address: benjamin.kay@wustl.edu.
Muriah D WheelockMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Joshua S SiegelDepartment of Psychiatry, New York University Langone Center for Psychedelic Medicine, New York, NY, USA.
Ryan V RautMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Allen Institute, Seattle, WA, USA; Department of Physiology & Biophysics, University of Washington, Seattle, WA, USA.
Roselyne J ChauvinDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Athanasia MetokiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Aishwarya RajeshAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Andrew EckMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jim PollaroMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Anxu WangDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Vahdeta SuljicDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Babatunde AdeyemoDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Noah J BadenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Julia S MonkDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Forrest I WhitingDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Nadeshka Ramirez-PerezDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Taylor Family Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, USA.
Samuel R KrimmelDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center, Perelman School of Medicine, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, Philadelphia, PA, USA; Center for AI and Data Science for Integrated Diagnostics, Perelman School of Medicine, Philadelphia, PA, USA.
Brenden Tervo-ClemmensDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Robert J M HermosilloMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Steven M NelsonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Timothy J HendricksonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Thomas MadisonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Lucille A MooreMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Óscar Miranda-DomínguezMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Anita RandolphMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Eric FeczkoMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Jarod L RolandAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Taylor Family Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, USA.
Ginger E NicolAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Timothy O LaumannAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Scott MarekAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Evan M GordonAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Marcus E RaichleDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Deanna M BarchMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Damien A FairMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Allied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA; Program in Occupational Therapy, Washington University in St. Louis, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MChild Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5MNIBIB NIH HHS K99 EB029343NIBIB NIH HHS R00 EB029343NIDA NIH HHS K23 DA057486NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIH HHS S10 OD025200NIH HHS S10 OD030477NIMH NIH HHS K99 MH121518NIMH NIH HHS K99 MH129616NIMH NIH HHS R00 MH121518NIMH NIH HHS R00 MH129616NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH129493NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NINDS NIH HHS K12 NS098482NINDS NIH HHS K23 NS123345NINDS NIH HHS K23 NS133486NINDS NIH HHS R01 NS140256NINDS NIH HHS R44 NS129521
Abstract
Prescription stimulants (e.g., methylphenidate) are thought to improve attention, but evidence from prior fMRI studies is conflicted. We utilized resting-state fMRI data from the Adolescent Brain Cognitive Development Study (n = 11,875; 8-11 years old) and validated the functional connectivity findings in a precision imaging drug trial with highly sampled (n = 5, 165-210 min each) healthy adults (methylphenidate 40 mg). Stimulant-related connectivity differences in sensorimotor regions matched fMRI patterns of daytime arousal, sleeping longer at night, and norepinephrine transporter expression. Taking stimulants reversed the effects of sleep deprivation on connectivity and school grades. Connectivity was also changed in salience and parietal memory networks, which are important for dopamine-mediated, reward-motivated learning, but not the brain's attention systems (e.g., dorsal attention network). The combined noradrenergic and dopaminergic effects of stimulants may drive brain organization towards a more wakeful and rewarded configuration, improving task effort and persistence without effects on attention networks.
Indexed as
ArousalAttentionCentral Nervous System StimulantsMethylphenidateRewardAdolescentAdultBrainChildFemaleHumansMagnetic Resonance ImagingMaleNorepinephrine Plasma Membrane Transport ProteinsSleep DeprivationCentral Nervous System StimulantsMethylphenidateNorepinephrine Plasma Membrane Transport ProteinsADHDarousalbrain networksbrain-wide association studiesfMRIfunctional connectivitymethylphenidateresting staterewardstimulants
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.