The effect of human papillomavirus vaccination during adolescence or early adulthood on incidence of spontaneous abortion in adulthood.

Alexandra R Hunt, Annette K Regan, Rebecca B Perkins, Lauren A Wise

Abstract read

In one paragraph

Article in Vaccine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra R HuntNewton South High School, Newton, MA 02459, USA.

Annette K ReganDivision of Epidemiologic Research, Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Ave, Pasadena, CA 91101, USA.

Rebecca B PerkinsDepartment of Obstetrics and Gynecology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. Electronic address: lwise@bu.edu.

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026

$6.7M

NICHD NIH HHS R01 HD086742

6 · The paper itself

Abstract

While human papillomavirus (HPV) infection has been associated with spontaneous abortion (SAB), there are limited data on HPV vaccination and SAB risk. We analyzed data from Pregnancy Study Online (PRESTO), a North American preconception cohort study (2013-2025). We followed 11,770 females aged 21-45 years for 12 months or until pregnancy, whichever came first. On baseline questionnaires, participants reported their HPV vaccination status and age at HPV vaccination. Participants reported pregnancy outcomes on follow-up questionnaires. We used Cox regression to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) adjusted for potential confounders. The prevalence of HPV vaccination was 52.9 %, and 20.4 % of participants experienced SAB. There was no appreciable association between HPV vaccination and SAB overall (HR = 0.95, 95 % CI: 0.87-1.04) or by age at vaccination (<18 years: HR = 1.03, 95 % CI: 0.92-1.16; ≥18 years: HR = 0.90, 95 % CI: 0.81-1.00). Results did not vary appreciably by timing of SAB (<6 vs. ≥6 weeks).

Indexed as

Abortion, SpontaneousPapillomavirus InfectionsPapillomavirus VaccinesVaccinationAdolescentAdultCohort StudiesFemaleHuman Papillomavirus VirusesHumansIncidenceMiddle AgedPregnancySurveys and QuestionnairesYoung AdultPapillomavirus VaccinesHuman papilloma virusMiscarriageProspective studiesSpontaneous abortionVaccines

Identifiers

PMID41448111

DOI10.1016/j.vaccine.2025.128152

PMCPMC13616216

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.