ReviewCurrent opinion in cell biology2026
Renaissance at the actin filament pointed end: Mechanisms of assembly, capping and depolymerization.
Review in Current opinion in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8Cell reports. Medicine · 2026Article
- Leiomodin 2 is a processive pointed-end elongator of actin filaments.Nature communications · 2026Article
- Leiomodin 2 functions as a processive pointed-end elongator of actin filaments.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cellular and biochemical studies of actin assembly have long focused primarily on reactions at the fast-growing barbed end of actin filaments. In contrast, the slow-growing pointed end has traditionally received comparatively less attention. Recent structural, biochemical, and cell biological studies have sparked a renaissance in pointed-end research, revealing its active roles in both actin assembly and disassembly. The discovery of pointed-end polymerization by the bacterial effector VopF has challenged the barbed-end centric assembly paradigm and reinvigorated efforts to identify endogenous pointed-end elongators. This review highlights the emerging molecular machinery and mechanisms governing pointed-end dynamics, including nucleation, elongation, capping, and disassembly. We discuss the physiological significance of pointed-end regulation and argue that a comprehensive understanding of actin regulation requires close attention to pointed end dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.