Evidence map›Paper›PMID 41447537›Full record

ArticleCell reports2026

Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion.

Maria Jassinskaja, Daniel Bode, Monika Gonka, Theodoros I Roumeliotis, Alexander J Hogg, Juan A Rubio Lara, Ellie Bennett, Joanna Milek, Samuel Elberfeld, Bart Theeuwes and 19 more

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Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Maria JassinskajaCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK; Lund Stem Cell Center, Division of Molecular Medicine and Gene Therapy, Lund University, Lund 221 84, Sweden.
Daniel BodeCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Monika GonkaCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Theodoros I RoumeliotisFunctional Proteomics Team, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, UK.
Alexander J HoggCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Juan A Rubio LaraCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK; Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Ellie BennettCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Joanna MilekCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Samuel ElberfeldCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Bart TheeuwesWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
M S VijayabaskarWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Lilia Cabrera CosmeCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
James Lok Chi CheCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK; Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Sandy MacDonaldDepartment of Biology, University of York, York YO10 5DD, UK.
Sophia AhmedDepartment of Biology, University of York, York YO10 5DD, UK.
Benjamin A HallDepartment of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, Gower Street, London WC1E 6BT, UK.
Grace VaseyCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Helena KooiCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Miriam BelmonteWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Mairi S ShepherdWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
William J BrackenburyCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Iwo KucinskiWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Satoshi YamazakiDivision of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Andrew N HoldingDepartment of Biology, University of York, York YO10 5DD, UK.
Alyssa H CullCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Nicola K WilsonWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Berthold GöttgensWellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0AW, UK.
Jyoti ChoudharyFunctional Proteomics Team, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, UK.
David G KentCentre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK. Electronic address: david.kent@york.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplexed, low-input mass spectrometry (MS)-based proteomics, we profile TET2-deficient (Tet2

Indexed as

DNA-Binding ProteinsHematopoietic Stem CellsMutationProteomicsProto-Oncogene ProteinsAnimalsCell ProliferationDioxygenasesExtracellular MatrixMiceMice, Inbred C57BLDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsTet2 protein, mousebiophysicsCP: stem cell researchextracellular matrixhematopoietic stem cellmulti-omicsphysical biologyproteomicsself-renewalsingle cell biologyTET2

Identifiers

PMID41447537
PMCPMC12847853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.