ArticleCell reports2026
Asynchronous firing and off states in working memory maintenance.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Repeatable, low-drift recordings in behaving non-human primates using flexible microelectrodes.bioRxiv : the preprint server for biology · 2026Article
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7 authors.
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Abstract
Persistent spiking activity and activity-silent mechanisms have been proposed as neural correlates of working memory. To determine their relative contribution, we recorded neural activity from the lateral prefrontal and posterior parietal cortex of two male macaques using high-density microelectrode probes. We found that, when averaged across all neurons, persistent delay activity was observable throughout the duration of single trials in populations of prefrontal neurons with silent periods that did not deviate significantly from chance. However, temporal fluctuations in activity-dependent mnemonic information were present and weakly correlated between the prefrontal and posterior parietal cortices, suggesting at least partial, long-distance synchronization of off states. The decoding accuracy of neurons recorded simultaneously was also reduced relative to pseudo-populations constructed by splicing different trials together. Our results support an asynchronous state of working memory, maintained by the distributed activity patterns, which is subject to widely distributed fluctuations in information representation fidelity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.