Evidence map›Paper›PMID 41447407›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Lower baseline serum neuronal-specific enolase levels predict better rate of recovery of functional walking ability in post-acute stroke patients.

Stefano Brunelli, Sami Nourbakhsh, Lorenzo Grimaldi, Alessandra Calvani, Noemi Gentileschi, Roberta Mucci, Eleonora Bovi, Emilia Giannella, Sofia Toniolo, Gisella Guerrera and 3 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefano BrunelliNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Sami NourbakhshNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Lorenzo GrimaldiBiobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Alessandra CalvaniNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Noemi GentileschiNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Roberta MucciNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Eleonora BoviBiobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Emilia GiannellaBiobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Sofia TonioloNuffield Department of Clinical Neurosciences, University of Oxford, Headington, Oxford, OX3 9DU, UK.
Gisella GuerreraNeuroimmunology Unit, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Luca BattistiniNeuroimmunology Unit, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Domenico De AngelisNeuroRehabilitation Unit 4, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy.
Giulia SancesarioBiobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, Rome, 00179, Italy. g.sancesario@hsantalucia.it.ORCID http://orcid.org/0000-0001-8365-164X

Funding

Ministero della Salute Ricerca corrente 2025
6 · The paper itself

Abstract

introductionEvaluate the association between functional recovery and a panel of specific neuronal biomarkers, in a cohort of stroke patients. MATERIAL AND

methodsSerum levels of neuronal specific enolase (NSE), neurofilament light chain (NfL), brain derived neurotrophic factor (BDNF), amyloid-β

resultsLinear regression was performed to predict changes in clinical scales during follow up, according to baseline biomarkers levels. NSE at T0 was a significant predictor of improvement in FAC and RMI, where the higher the NSE concentration, the smaller the improvement. Therefore, baseline NSE explained 39% of the variation in FAC and 31% in RMI over time. No significant differences were observed with respect to other scales or other biomarkers.

conclusionsThis exploratory study suggested that serum NSE may be a predictor of functional mobility recovery in post-acute stroke patients and represents a useful tool for patients' stratification.

Indexed as

Phosphopyruvate HydrataseRecovery of FunctionStrokeWalkingAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleHumansMaleMiddle AgedNeurofilament ProteinsPeptide FragmentsPredictive Value of TestsStroke RehabilitationAmyloid beta-PeptidesBiomarkersENO2 protein, humanneurofilament protein LNeurofilament ProteinsPeptide FragmentsPhosphopyruvate Hydratasetau ProteinsBlood biomarkersBrain-derived neurotrophic factorNeurodegenerationNeuronal specific enolaseRehabilitationStroke

Identifiers

PMID41447407
PMCPMC12740951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.