Evidence map›Paper›PMID 41447403›Full record

ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2026

From pain relief to mucosal grief: A comprehensive review of NSAID enteropathy.

Harsh Srivastava, Tanisha Sehgal, Varun Mehta, Jeffrey Berinstein, Shrinivas Bishu, Manjeet Kumar Goyal

Abstract readReview
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In one paragraph

Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harsh SrivastavaDepartment of Medicine, VMMC and Safdarjung Hospital, New Delhi, 110 029, India.
Tanisha SehgalDepartment of Medicine, Dayanand Medical College and Hospital, Ludhiana, 141 001, India.
Varun MehtaDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India.
Jeffrey BerinsteinDivision of Gastroenterology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Shrinivas BishuDivision of Gastroenterology, Department of Medicine, Michigan Medicine, Ann Arbor, USA.
Manjeet Kumar GoyalDepartment of Gastroenterology, University of Michigan Medicine: University of Michigan Michigan Medicine, Ann Arbor, USA. manjeetgoyal@gmail.com.ORCID http://orcid.org/0000-0002-5511-2099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are essential for their analgesic, anti-inflammatory and anti-pyretic properties. However, their extended use can lead to NSAID enteropathy, a frequently underdiagnosed condition of the small intestine. This pathology manifests as mucosal damage, ulcerations, strictures and increased intestinal permeability, potentially resulting in complications such as bleeding, protein loss and nutrient malabsorption. Modern diagnostic technologies, particularly capsule endoscopy, have revealed that small-bowel injury affects up to 70% of chronic NSAID users, although many patients remain asymptomatic. This comprehensive review explores the epidemiology, underlying mechanisms, clinical manifestations, diagnostic approaches and treatment strategies for NSAID enteropathy, while emphasizing the growing importance of increased clinical awareness and continued research into preventive and therapeutic interventions, especially as long-term NSAID use becomes more prevalent in our aging global population.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalIntestinal DiseasesIntestinal MucosaIntestine, SmallCapsule EndoscopyHumansAnti-Inflammatory Agents, Non-SteroidalCapsule endoscopyCyclooxygenase inhibitionGastrointestinal complicationsIntestinal permeabilityNSAID enteropathySmall-bowel injury

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.