ArticlePM & R : the journal of injury, function, and rehabilitation2026
Increased symptomatic autonomic dysfunction is associated with greater cardiovascular endothelial dysfunction following spinal cord injury.
Article in PM & R : the journal of injury, function, and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Increased symptomatic autonomic dysfunction is associated with greater cardiovascular endothelial dysfunction following spinal cord injury.PM & R : the journal of injury, function, and rehabilitation · 2026Article
- Reduced skeletal muscle perfusion accompanies skeletal muscle atrophy after severe spinal cord injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIndividuals with spinal cord injury (SCI) are known to have high rates of cardiovascular disease that have traditionally been attributed to inability to engage in adequate intensity exercise. However, individuals with SCI also commonly experience instability in blood pressure. Blood pressure fluctuations are known to contribute to cardiovascular disease in other conditions, though this relationship in SCI is unknown.
objectiveTo evaluate correlations between a clinical history of symptomatic blood pressure instability and objective evidence of vascular endothelial dysfunction in individuals with SCI.
designCase control.
settingAcademic medical center.
participantsTwenty-four individuals with SCI, 14 uninjured controls of matched age, gender, and body mass index.
interventionsNot applicable.
main outcome measuresSymptomatic blood pressure instability was measured by the Autonomic Dysfunction Following SCI (ADFSCI) survey. Vascular endothelial dysfunction was quantified by ultrasound recordings of brachial flow mediated dilation following 5 minutes of forearm arterial occlusion.
resultsTotal ADFSCI scores were significantly higher in individuals with SCI compared to controls (41.0 vs. 9.0, p = .002). Both percentage of brachial flow mediated dilation and consensus recommended allometrically scaled percentage of flow mediated dilation were significantly less in individuals with SCI (p < .001 for both), demonstrating greater vascular dysfunction. More symptoms of blood pressure instability on the ADFSCI survey were correlated with more objective evidence of vascular dysfunction (R
conclusionsIn individuals with SCI, more severe symptoms of blood pressure instability are significantly correlated with more severe vascular endothelial dysfunction, making management of orthostatic hypotension and autonomic dysreflexia both high potential, modifiable risk factors for individuals with SCI to mitigate cardiovascular disease.
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