ArticleTurkish journal of ophthalmology2025
Anterior Segment OCT Imaging of Bleb Morphological Changes as Predictors of Success After Bleb Needling.
Article in Turkish journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To determine the bleb morphology and anterior segment changes after needling in trabeculectomy patients with filtration failure by anterior segment-optical coherence tomography (AS-OCT), and to identify morphological predictors of success. Materials and Methods: Thirty-two eyes of 32 patients who underwent trabeculectomy with mitomycin C and experienced filtration failure underwent bleb needling with subconjunctival 5-fluorouracil injection. AS-OCT imaging was performed before and at several time points up to 6 months post-needling. Intraocular pressure (IOP), anterior chamber depth, and bleb height and width were measured. Complete success was defined as achieving IOP ≤19 mmHg without medication, and qualified success as IOP ≤19 mmHg with medication at 6 months. Results: The mean age of the patients was 61.7±7.8 years (range, 44-76), and the mean interval between trabeculectomy and needling was 6.6±6.1 months (range, 1-26). IOP was 27.70±5.11 mmHg preoperatively (preop), 18.32±7.51 mmHg at 1 month, and 20.90±7.03 mmHg at 6 months. The decrease in IOP was statistically significant (p=0.015 and p=0.397, respectively). Bleb width was 3.74±0.67 mm preop, 4.16±0.55 mm at 1 month, and 3.9±0.49 mm at 6 months (p=0.001 and p=0.047, respectively). Bleb height was 0.45±0.16 mm preop, 0.41±0.11 mm at 1 month, and 0.40±0.11 mm at 6 months (p=0.812 and p=0.249, respectively). The success rate of needling was 75% at 1 month and 40.6% at 6 months. There were significant differences in age, preop IOP, and bleb height after needling between indistinct and encapsulated blebs. Choroidal effusion developed in 3 patients and resolved with medical treatment. Ahmed glaucoma valve implantation was performed in 6 patients who could not reach the target IOP. Conclusion: AS-OCT imaging provides an objective and reproducible evaluation of bleb morphological changes after needling. Reduced bleb height, particularly in encapsulated blebs, and increased microcyst density observed on AS-OCT predict successful aqueous humor drainage. Incorporating AS-OCT assessments into clinical practice could improve postoperative management by enabling early detection of bleb dysfunction and guiding timely interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.