ArticleFrontiers in medicine2025
Case report: A rare case of IgA nephropathy associated with type II Abernethy malformation.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Abernethy malformation is a rare congenital vascular anomaly involving extrahepatic portosystemic shunting, with only a handful of reported cases coexisting with IgA nephropathy. We present a case of a patient who initially manifested with proteinuria and hematuria, and later developed hepatic encephalopathy, prompting vascular imaging that identified a type II Abernethy malformation characterized by an extrahepatic portocaval shunt. A diagnosis of type II Abernethy malformation was established. The patient underwent laparoscopic partial shunt disconnection, which led to a marked reduction in proteinuria (from 0.8-2.1 g/d to 0.19-0.29 g/d). This case, along with previous reports, suggests that portosystemic shunting in Abernethy malformation may be a pathogenic factor in IgA nephropathy. Surgical correction of the shunt may confer renal benefits in selected cases and deserves further investigation.
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