ArticleRadiology advances2025
Automated synthetic contrast-enhanced MRI improves choroid plexus segmentation in Parkinsonian syndromes.
Article in Radiology advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Choroid plexus (ChP) has gained attention as a potential biomarker in neurodegenerative diseases, yet its segmentation remains challenging. Gadolinium-based contrast-enhanced MRI (CE-MRI) is the reference standard, as non-contrast MRI images lack sufficient contrast. However, gadolinium deposition, risk of nephrogenic system fibrosis in renally impaired patients, and patient discomfort limit its repeated administration. Purpose: To develop deep learning-based synthetic-contrast-enhanced MRI (SynCE-MRI) using T1-weighted images to improve ChP visualization and evaluate its ability to detect morphological changes in Parkinsonian syndromes. Materials and methods: This retrospective study included 265 (mean age = 65.7 ± 7.00 years, males/females: 120/145) consecutive patients in the internal cohort (174 with Parkinson's disease [PD], 46 with essential tremor, and 45 with atypical Parkinsonian disorder [APD]) who underwent T1W and CE-MRI at 3T from Asan Medical Center (June 2021-December 2023), and an external cohort of 58 (mean age = 60.7 ± 7.8 years, males/females: 40/18) patients (29/29 PD/APD) from Pusan National University, Yangsan Hospital (April 2011-December 2014). Nested-UNet was used for SynCE-MRI synthesis from T1W images. The 3D-UNet ChP segmentation model was trained by CE-MRI and tested using SynCE-MRI. Kruskal-Wallis and Bonferroni-corrected Mann-Whitney Results: SynCE-MRI achieved high-fidelity images with peak signal-to-noise ratio (PSNR) 35.37 ± 1.32 and structural similarity index measure (SSIM) 0.970 ±0.0054. Segmentation accuracy for SynCE-MRI (dice score = 0.803 ± 0.029, 95% CI: 0.797-0.810) significantly outperformed manual (dice score = 0.59 ± 0.057, 95% CI: 0.578-0.603; Conclusion: SynCE-MRI accurately replicates CE-MRI for ChP imaging and morphometry, outperforms T1W imaging in segmentation, and detects ChP enlargement in APD versus PD across internal and external cohorts, consistent with CE-MRI findings.
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