Evidence map›Paper›PMID 41446745›Full record

ArticleiScience2025

Profiling truncated variants of TCTN1 unveils the essential role of its integrity for ciliogenesis.

Huimin Yu, Lin Jiang, Chuang Xu, Ya Li, Suhui Wang, Zhao Ma, Yunyao Qian, Yiqiong Wu, Chenyu Miao, Zhouzhou Dong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huimin YuSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Lin JiangSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Chuang XuSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Ya LiSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Suhui WangSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Zhao MaSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Yunyao QianSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Yiqiong WuSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Chenyu MiaoSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Zhouzhou DongSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Liang WangSchool of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cilia protrude from the cell surface to execute signal transduction and cell motility. Tectonic (TCTN) is a transition-zone (TZ) "gatekeeper" that determines ciliary composition and function. The role of its only conserved module in the TCTN protein family, DUF1619, lacks functional annotation. Herein, we quantitatively compared full-length TCTN1 and four truncations (DUF1619, ΔDUF1619, N-DUF1619, and DUF1619-C) stably expressed in

Indexed as

BiochemistryBiological sciencesCell biologyNatural sciences

Identifiers

PMID41446745
PMCPMC12723291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.