Evidence map›Paper›PMID 41446732›Full record

ArticleiScience2025

Landmark vector cells in the absence of visual input.

Vyash Puliyadi, Ravikrishnan P Jayakumar, Jeremy L Johnson, Tammy T Tran, Sachin S Deshmukh, James J Knierim

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vyash PuliyadiDepartment of Psychological and Brain Sciences, Johns Hopkins University, School of Arts and Sciences, Baltimore, MD, USA.
Ravikrishnan P JayakumarZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
Jeremy L JohnsonZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
Tammy T TranDepartment of Psychology, Stanford University, Palo Alto, CA, USA.
Sachin S DeshmukhZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
James J KnierimDepartment of Psychological and Brain Sciences, Johns Hopkins University, School of Arts and Sciences, Baltimore, MD, USA.

Funding

MULTI-SITE ANALYSIS OF HIPPOCAMPAL NEURONAL ENSEMBLESR01NS039456 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JAMES J KNIERIM · 2000 to 2026
$9.1M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
Neural representations of external stimuli in the lateral entorhinal cortexR01MH094146 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KNIERIM, JAMES J · 2011 to 2015
$2.0M
NIA NIH HHS T32 AG027668NIMH NIH HHS R01 MH094146NINDS NIH HHS R01 NS039456
6 · The paper itself

Abstract

Spatial landmarks are critical reference points for navigation. An animal's position relative to spatial landmarks is represented by hippocampal landmark vector cells (LVCs), which exhibit spatial firing fields at an equivalent allocentric angle and distance to landmarks. It is unknown whether visual inputs are necessary for the formation and maintenance of LVCs. In rats exploring a novel platform with landmarks in complete darkness, LVCs were present in CA1. Their vector fields moved along with the landmarks and maintained their spatial selectivity when the landmarks were removed. In an update to McNaughton's model of vector encoding, we demonstrate how changes in entorhinal inputs can result in the phenotypes we observe in place cells and LVCs. This model suggests that these two spatial neurons may be unified by a common computational mechanism, with differences in spatial firing patterns resulting from differences in egocentric inputs.

Indexed as

behavioral neurosciencebiological sciencesneuroscience

Identifiers

PMID41446732
PMCPMC12723168

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.