Evidence map›Paper›PMID 41446731›Full record

ArticleiScience2025

MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury.

Meimei Li, Yan Wang, Zihan Zhang, Yuanyuan Gao, Fanglian Chen, Ping Lei, Xintong Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meimei LiDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Yan WangDepartment of General Practice, Tianjin Medical University General Hospital, Tianjin, China.
Zihan ZhangThe School of Medicine, Nankai University, Tianjin, China.
Yuanyuan GaoDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Fanglian ChenDepartment of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.
Ping LeiDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Xintong GeDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive mild traumatic brain injury (rmTBI) is an important risk factor for neurodegeneration, with early blood-brain barrier (BBB) disruption playing a key role. Clinical outcome heterogeneity may stem from region-specific disparities in white matter integrity and metabolic homeostasis linked to BBB permeability. Using a controlled cortical impact mouse model, we observed marked BBB disruption (Evans blue leakage, downregulation of ZO-1/claudin-5), accompanied by microglial activation and a pro-inflammatory cytokine shift (elevated IL-6 and reduced IL-4/IL-10). Magnetic resonance imaging-diffusion tensor imaging (MRI-DTI) using tract-based spatial statistics (TBSS) and voxel-based analysis (VBA) analysis revealed diffuse white matter injury in regions like the olfactory bulb and hypothalamus, while

Indexed as

Cell biologyMolecular biologyNeuroscience

Identifiers

PMID41446731
PMCPMC12723284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.