ArticleiScience2025
Targeted proteomics reveals immune protein patterns in serum from patients with calcific aortic stenosis.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Investigation of plasma-derived extracellular vesicles in hypertrophic cardiomyopathy patients.iScience · 2026Article
- From Valve Anatomy to Molecular Trajectories: Integrating Proteomics into Precision Care for Bicuspid Aortic Valve Disease.Journal of cardiovascular development and disease · 2026Review
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Authors and funding
10 authors.
Funding
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Abstract
Calcific aortic valve disease (CAVD) is a progressive condition with poor prognosis once symptomatic. The disease's progression is driven by a combination of mechanical stress, lipid infiltration, and immune responses, which involve both innate and adaptive immune systems. To explore the role of immune-related proteins in CAVD, we applied a targeted proteomic approach based on the proximity extension assay technique. Ten proteins were downregulated in patients with CAVD with respect to control subjects, indicating disrupted biological processes such as redox homeostasis, immune response, and cell motility. A protein-protein interaction network revealed connections between these proteins, with notable clusters associated with immune regulation and redox homeostasis. Further analysis identified two distinct patient subgroups, suggesting heterogeneity among patients with CAVD, which could help with patient stratification. The study identified proteins that may serve as candidate biomarkers for early detection of CAVD and emphasizes the role of immune-driven mechanisms in CAVD.
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