Evidence map›Paper›PMID 41446728›Full record

ArticleiScience2025

Single-cell transcriptomic landscape of keratinocyte transformation from actinic keratosis to skin carcinoma.

Tao Xu, Zhongzhi Wang, Hao Wu, Yuanjie Zhu, Liangzhe Wang, Siyu Wu, Ti Fu, Xiaolie Wang, Guotai Yao, Shengli Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tao XuDepartment of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Zhongzhi WangDepartment of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Hao WuPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Yuanjie ZhuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Liangzhe WangDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Siyu WuDepartment of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Ti FuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Xiaolie WangDepartment of Dermatology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Guotai YaoDepartment of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Shengli LiPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Yi JinDepartment of Dermatology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Jianghan ChenDepartment of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) develops through a stepwise progression from normal skin (NS) to actinic keratosis (AK) and invasive carcinoma. To delineate the cellular and molecular events underlying this transition, we perform single-cell RNA sequencing on 65,485 cells from NS, AK, and cSCC tissues. The analysis revealed dynamic remodeling of keratinocyte, T cell, and B cell populations during disease progression. A progressively expanding

Indexed as

CancerImmune responseTranscriptomics

Identifiers

PMID41446728
PMCPMC12723273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.