Evidence map›Paper›PMID 41446701›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients.

Katelyn A Bruno, R Scott Wright, Joshua Culberson, Mikolaj A Wieczorek, David O Hodge, Patrick W Johnson, Yomary A Jimenez, Emily R Whelan, Jose M Malavet, Kathryn F Larson and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04338360 (Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04338360 approved for marketingnot on this map

Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19

Typeexpanded_accessSponsorMayo ClinicConditionsCOVID19ArmsCOVID-19 convalescent plasma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Katelyn A BrunoDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.
R Scott WrightDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.
Joshua CulbersonDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.
Mikolaj A WieczorekDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States of America.
David O HodgeDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States of America.
Patrick W JohnsonDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States of America.
Yomary A JimenezDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States of America.
Emily R WhelanDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.
Jose M MalavetDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.
Kathryn F LarsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.
Jonathon W SenefeldDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America.
Chad C WigginsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America.
Stephen A KlassenDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Jacob RicciDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States of America.
Taimur SherDepartment of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States of America.
Rickey E CarterDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States of America.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America.
DeLisa FairweatherDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.
Allan S JaffeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
Role of mitochondrial extracellular vesicles in CVB3 myocarditis by sexR01HL164520 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2022 to 2025
$3.0M
Role of viral mitophagosomes in driving sex differences in myocarditisR21AI145356 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, SIN, JON · 2019 to 2020
$463k
Vitamin D Binding Protein (DBP) in Innate Immune Cell Response in Viral MyocarditisR21AI163302 · NIAID · UNIVERSITY OF FLORIDA · PI BRUNO, KATELYN ANN · 2021 to 2022
$430k
Adipose-derived biogenic nanoparticles for treatment of myocarditis/DCM(MPDPI)R21AI152318 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, WOLFRAM, JOY · 2020 to 2021
$430k
Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult populations: role of sex, age and hormone statusR21AI180863 · NIAID · UNIVERSITY OF FLORIDA · PI BRUNO, KATELYN ANN · 2024 to 2025
$413k
NCATS NIH HHS UL1 TR002377NHLBI NIH HHS R01 HL164520NHLBI NIH HHS R35 HL139854NIAID NIH HHS R21 AI145356NIAID NIH HHS R21 AI152318NIAID NIH HHS R21 AI163302NIAID NIH HHS R21 AI180863NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

Objective: To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age. Methods: We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April-August 2020) of the COVID-19 pandemic. Results: We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age. Conclusion: These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups.Clinical Trials registration number: NCT04338360.

Indexed as

Convalescent plasmaCoronavirus disease 2019High sensitivity troponin

Identifiers

PMID41446701
PMCPMC12723113

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.