Evidence map›Paper›PMID 41446626›Full record

ReviewChemical science2026

Chemically modified DNA aptamers and DNAzymes for expanded functional capabilities.

Canyu Zhang, Ke-Siyi Ma, Zifan Zhang, Wenyong Lou, Hongzhou Gu, Yufei Cao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Canyu ZhangLab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology Guangzhou 510640 Guangdong China yufeicao@scut.edu.cn.
Ke-Siyi MaLab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology Guangzhou 510640 Guangdong China yufeicao@scut.edu.cn.
Zifan ZhangLab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology Guangzhou 510640 Guangdong China yufeicao@scut.edu.cn.
Wenyong LouLab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology Guangzhou 510640 Guangdong China yufeicao@scut.edu.cn.ORCID https://orcid.org/0000-0003-3474-3446
Hongzhou GuDepartment of Chemical Biology, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University Shanghai 200240 Shanghai China hongzhou.gu@sjtu.edu.cn.
Yufei CaoLab of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology Guangzhou 510640 Guangdong China yufeicao@scut.edu.cn.ORCID https://orcid.org/0000-0002-4742-4009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA aptamers and DNAzymes, typically single-stranded DNA (ssDNA), are often selected through systematic evolution of ligands by exponential enrichment (SELEX), and have demonstrated great potential across various applications. However, the inherent properties and limited chemical space of ssDNA pose challenges in terms of stability and functionality. Chemical modifications have emerged as a powerful strategy to enhance the stability and extend the functionality of these molecules. In this review, we summarize the types of chemical modifications applied to DNA aptamers and DNAzymes, and highlight representative examples from the past five years that demonstrate how these modifications expand their functional capabilities. We also discuss the current challenges and future directions in advancing the methodologies and toolsets necessary to accelerate the development of chemically modified functional DNAs, aiming to further broaden their structural diversity, functional complexity, and application potential.

Identifiers

PMID41446626
PMCPMC12723606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.