Evidence map›Paper›PMID 41446565›Full record

ArticleDrug target insights

Antioxidant potential of a new macrocyclic bisbibenzyl and other compounds from

Angele Fanta, Gaetan Bayiha Ba Njock, Amadou Dawe, Fawai Yakai, Jean Noël Nyemb, Herve Landry Ketsemen, Vincent Taira, Albert Wangso, Chantal Doudja, Dieudonne Emmanuel Pegnyemb and 1 more

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In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angele FantaDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.
Gaetan Bayiha Ba NjockDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.ORCID https://orcid.org/0000-0001-6882-9091
Amadou DaweDepartment of Chemistry, Higher Teachers Training College, University of Maroua, Maroua - Cameroon.
Fawai YakaiDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.
Jean Noël NyembDepartment of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaélé - Cameroon.ORCID https://orcid.org/0000-0001-5069-6737
Herve Landry KetsemenDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé - Cameroon.ORCID https://orcid.org/0009-0007-1874-690X
Vincent TairaDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.
Albert WangsoDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.
Chantal DoudjaDepartment of Chemistry, Faculty of Science, University of Maroua, Maroua - Cameroon.
Dieudonne Emmanuel PegnyembDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé - Cameroon.
Benoit LouraDepartment of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaélé - Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Free radicals are key contributors to several diseases, including cancer, inflammation, pain, and neurodegenerative disorders such as Alzheimer's disease. Due to the limitations and adverse effects of synthetic antioxidants, naturally occurring phytochemicals offer safer, more sustainable alternatives. This study investigates the antioxidant potential of twigs of Methods: Compounds were isolated using chromatographic methods, and their structures established by 1D- and 2D-NMR, HR-ESI-MS, and comparison with reported data. Antioxidant activity was assessed through DPPH radical scavenging and FRAP assays, while molecular docking against xanthine oxidase (PDB: 1FIQ) explored possible mechanisms beyond direct radical scavenging. Results: A new macrocyclic bisbibenzyl derivative, combrebisbibenzyl A ( Conclusion: These findings support the traditional use of

Indexed as

Antioxidant activityCombrebisbibenzyl ACombretum molleMacrocyclic bis-bibenzylMolecular docking

Identifiers

PMID41446565
PMCPMC12723388

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.