ArticleBiochemistry research international2025
Tetrahydrocurcumin (THC) as a Melanogenesis Inhibitor in Melanoma Cell Lines.
Article in Biochemistry research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence.International journal of molecular sciences · 2026Review
- Pogostemon Cablin Aqueous Extract (PCAE) Induces Mitotic Delay by Downregulating CDC2/Cyclin B1 in TNBC Cells (MDA-MB-231).Biochemistry research international · 2026Article
- Tetrahydrocurcumin (THC) as a Melanogenesis Inhibitor in Melanoma Cell Lines.Biochemistry research international · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanin plays significant roles in biophysical, biochemical, light-filtering, and cosmetic functions of the skin. The melanin content in pigmented cells, such as melanoma cells, can be accurately measured. This study focused on evaluating the effects of tetrahydrocurcumin (THC), a hydrogenated derivative of curcuminoids, on melanogenesis in melanoma cells. We specifically investigated how THC influences melanin production and tyrosinase activity, a key enzyme in the melanogenesis pathway, in A375 melanoma cells. Our results provide experimental evidence supporting THC's potential as an inhibitor of melanin synthesis and tyrosinase activity. This suggests that THC could be an effective component in skin-whitening products. By demonstrating THC's ability to suppress melanin content and tyrosinase activity, our study highlights its potential for use as a dermatological agent in skincare formulations aimed at reducing pigmentation.
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Registered trials
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