ReviewCureus2025
Off-Clamp Versus On-Clamp Robot-Assisted Partial Nephrectomy: A Meta-Analysis of Clinical Trials and Matched Cohort Studies.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bipolar electrocautery hemostasis in sutureless laparoscopic partial nephrectomy for exophytic small renal masses under zero-ischemia: a retrospective single-center experience.Translational andrology and urology · 2026Article
- Robotic partial nephrectomy is inching toward the gold standard for small renal masses-a narrative review.Translational andrology and urology · 2026Review
- On-Clamp Versus Off-Clamp Robot-Assisted Partial Nephrectomy for Localized Renal Tumors: A Retrospective Single-Center Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney cancer incidence continues to rise globally, with partial nephrectomy established as the standard of care for localized renal masses. Robot-assisted partial nephrectomy has become the preferred approach, with debate continuing regarding the optimal management of renal blood flow during tumor excision. While on-clamp techniques involve temporary renal artery occlusion to minimize blood loss, off-clamp approaches avoid ischemic injury by maintaining continuous renal perfusion. This meta-analysis aimed to compare perioperative, functional, and oncological outcomes between off-clamp and on-clamp robot-assisted partial nephrectomy. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Web of Science, Scopus, and Cochrane databases. Twenty studies, comprising two randomized controlled trials and 18 observational studies, were included, totaling 4,961 patients after matching. Quality assessment utilized the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias 2 tool for randomized trials. Meta-analysis employed risk ratios (RRs) for dichotomous outcomes and mean differences (MDs) for continuous variables, with random-effects models applied when heterogeneity exceeded 50%. Publication bias was assessed using funnel plots and Egger's regression test. Off-clamp robot-assisted partial nephrectomy demonstrated significantly lower major complication rates compared to on-clamp techniques (RR: 1.66, p = 0.018). Renal function preservation favored the off-clamp approach, with better postoperative glomerular filtration rate (MD: -3.45 mL/min/1.73 m
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.