ArticleCureus2025
Peutz-Jeghers Syndrome With Malignant Transformation in a Hamartomatous Rectal Polyp: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Peutz-Jeghers syndrome (PJS) is a rare hereditary condition characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyps. We describe the case of a 14-year-old girl who presented with rectal bleeding, in whom endoscopic evaluation revealed multiple hamartomatous polyps, including two large rectal lesions. Histopathological analysis showed areas of high-grade dysplasia and in situ carcinoma developing within a hamartomatous polyp. Although this syndrome is generally benign, affected individuals have a lifelong predisposition to gastrointestinal and extra-digestive malignancies. Malignant transformation during adolescence is exceptionally uncommon, highlighting the importance of early diagnosis and structured surveillance to reduce cancer risk.
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