ArticleCureus2025
Pathogenic MAX Variant in Bilateral Adrenal Paragangliomas: The Dilemma of Cortical-Sparing Surgery.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
We describe the case of a woman in her late 30s presenting with signs and symptoms of catecholamine excess and asymmetric bilateral adrenal lesions. Initial genetic testing was negative, including analysis of RET, VHL, SDH genes, TMEM127, and MAX. She underwent right cortical-sparing adrenalectomy, which normalized biochemical markers and blood pressure. One year later, she developed recurrent catecholamine excess, and repeat genetic analysis identified a germline pathogenic variant in MAX. Functional imaging confirmed a contralateral adrenal lesion, raising considerations regarding oncological safety versus adrenal preservation. This case highlights the complexity of hereditary pheochromocytoma/paraganglioma syndromes and illustrates how evolving genetic testing can influence surgical decision-making.
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