ReviewCureus2025
Anatomical Variations of the Foramen Ovale and Trigeminal Neuralgia.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Emerging Pharmacological Strategies for Trigeminal Neuralgia.CNS drugs · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The foramen ovale (FO) is a prominent foramen situated in the middle cranial fossa, allowing passage for a branch of the trigeminal (Vth cranial) nerve, along with the accessory meningeal artery, an emissary vein, and potentially other anatomical features. Initially, it develops as a ring-shaped foramen, but upon complete ossification, its shape varies, with potential differences in size and form as well. This research aims to investigate the diverse anatomical variations of the FO and their implications for the structures traversing it, particularly the third branch of the trigeminal nerve, which may lead to neuropathies such as trigeminal neuralgia. The study utilized databases like PubMed and Scopus, employing the sentence "Anatomical variations of the foramen ovale and trigeminal neuralgia," along with supplementary retrieval from the bibliographies of relevant articles. In addition to the bibliography retrieved from the bases, a secondary search of articles from the selected bibliographies was also performed. A total of 84 articles were found, of which our study includes 19 articles that meet the selection criteria. The examination revealed numerous possible variations, not only in shape but also in the morphometric properties of the FO. These variations in dimensions and the presence of additional bony formations may influence the anatomical structures passing through it, potentially leading to their entrapment or compression, and resulting in neurological symptoms, specifically trigeminal neuralgia. Consequently, there are documented instances of trigeminal neuralgia linked to vascular compression and the entrapment of the trigeminal nerve. However, further investigation into the various hypotheses surrounding its etiology is essential to elucidate the specific mechanisms underlying the neuropathy, thereby enabling medical specialists to better manage patients with trigeminal neuralgia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.