ArticleCureus2025
Comparative Efficacy of Janus Kinase Inhibitors (JAKis) for Ulcerative Colitis in Japanese Regional Healthcare Facilities: A Real-World Database Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
BACKGROUND AND
aimTofacitinib (TOF), filgotinib (FIL), and upadacitinib (UPA) are approved Janus kinase inhibitors (JAKis) for ulcerative colitis (UC), but real-world comparative data remain limited. This study assessed their efficacy, persistence, and safety in regional Japanese hospitals.
methodsWe retrospectively analyzed 148 UC treatment sessions (TOF, 60; FIL, 53; UPA, 35). The primary outcome was clinical remission (partial Mayo score ≤1 with rectal bleeding score 0). Secondary outcomes included clinical response, steroid-free remission, and treatment persistence. Adverse events and biologics (Bio)/JAKi subgroup data were collected.
resultsAt week 8, clinical remission rates were similar for TOF (46%), FIL (44%), and UPA (46%). At week 24, FIL had the highest remission rate (61%) vs. TOF (46%) and UPA (41%), a trend that continued at week 48 (59%, 41%, 44%). FIL also showed the highest remission in both Bio/JAKi-naïve and failure sessions at weeks 24 and 48. UPA had the highest clinical response at week 8 (67%). TOF showed stable remission over time (46%, 46%, 41%). Steroid-free remission was more frequent with FIL at weeks 24 (61%) and 48 (59%) than with TOF (46%, 41%) or UPA (35%, 33%). Persistence was similar across agents through week 24. Safety profiles aligned with prior data, though rare events such as
conclusionsFIL showed favorable remission rates, especially in Bio/JAKi-naïve patients, and remained effective after prior failures, suggesting broad applicability. UPA and TOF showed similar remission rates in our cohort.
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