ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025
Impact of institutional treatment guidance on the management and outcomes of
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Pathogen characteristics and pre-index clinical factors associated with multidrug-resistant organism infections in intensive care unit patients.Frontiers in public health · 2026Observational
- Improved guideline adherence may not overcome evidence gaps in severe trimethoprim-sulfamethoxazole-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the impact of a guidance document on treatment decisions and clinical outcomes for infections caused by carbapenem-resistant Design: This was a single-center, retrospective, quasi-experimental, pre- and post-intervention study. The primary outcome was adherence to antibiotic selection and dosing as recommended by the guidance document. Secondary outcomes included clinical efficacy, readmission within 90 days, all-cause 30-day mortality, 90-day microbiologic recurrence, and antibiotic-associated adverse effects. Setting: The study was conducted at a large, academic medical center in the Southeastern United States. Participants: The study included adult patients who were admitted to our institution from November 2018 to June 2024 who grew CRAB or Intervention: This study included an institution specific treatment algorithm for the treatment of infections caused by resistant gram-negative organisms published on June 1 Results: Twenty-two patients with CRAB (14 pre- and 8 post-intervention) and 150 with Conclusions: These findings demonstrate that implementing a local treatment guideline based on IDSA guidance may increase the utilization of evidence-based directed antimicrobial therapy for CRAB and
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Registered trials
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