ArticleHealth science reports2025
A Potential Role of Intraoperative Lidocaine in Patients Undergoing Thyroidectomy-An Original Systematic Review and Meta-Analysis.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of intravenous lidocaine in thyroidectomy: a systematic review and meta-analysis with trial sequential analysis and meta-regression.BMC anesthesiology · 2026Pooled it
- A Potential Role of Intraoperative Lidocaine in Patients Undergoing Thyroidectomy-An Original Systematic Review and Meta-Analysis.Health science reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Thyroidectomy is a routine operation for diverse thyroid diseases between benign and malignant. In such cases, the complications and postoperative pains, such as nausea, vomiting, and hemodynamic instability, complicate recovery and lengthen hospital stays. Lidocaine may prove beneficial due to its analgesic, anti-inflammatory, and antihyperalgesic actions. The current systematic review and meta-analysis assessed the effect of IV lidocaine infusion on postoperative pain and its complications in patients undergoing total thyroidectomy. Methods: A systematic review of published RCTs between 2016 and 2023 was conducted using PubMed, Embase, and Google Scholar. Their inclusion criteria were the comparison of IV lidocaine versus placebo in managing patients undergoing thyroidectomy. The primary outcomes included postoperative pain by VAS measurements. Secondary outcomes included MAP, heart rate at extubation, and PONV. A random effects model was applied for the analysis, whereas statistical evaluation was done using RevMan 5.2. Results: A total of five RCTs of 375 patients were summarized, where 172 patients were in the lidocaine group and 203 in the placebo group. Significant reduction in postoperative pain of IV lidocaine was shown (SMD = -1.24; 95% CI: -2.7 to 0.30; Conclusion: IV lidocaine shows potential in reducing postoperative pain, improving hemodynamic stability, and decreasing cough incidence in thyroidectomy patients. However, its effect on PONV remains unclear, warranting further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.