Circuitry correlates of negative urgency and suicidality in schizophrenia spectrum disorders: a LASSO regression study.

Objective: Suicidality is highly prevalent with vast public health implications. The association between schizophrenia spectrum disorders (SSDs) and suicidal ideation and related behaviors (SIBs) is well established. One construct that has received less attention is Method: We used least absolute shrinkage and selection operator (LASSO) logistic regression to generate classifications of individuals recruited as high-risk (n=14) and low-risk (n=16) for SIBs (n=30, M Results: Model 1 suggested that greater hostility, guilt, and negative urgency predicted higher likelihood of belonging to the high-risk group, whereas greater difficulty with abstract thinking predicted lower likelihood of belonging to the high-risk group. Model 2 suggested that greater hostility predicted higher likelihood of high-risk, whereas greater anterior cingulate thickness and increased activity in six brain regions-right superior frontal gyrus, left superior medial frontal gyrus, left superior frontal gyrus, right middle frontal gyrus, and right middle cingulate gyrus-predicted a lower likelihood of high SIB. Discussion: Negative urgency and SSD symptoms can classify high-and low-risk groups accurately, and inclusion of brain data slightly increased predictive accuracy.